Cortical Gray Matter Proteins Associated With Cerebral Amyloid Angiopathy in Community-Dwelling Older Adults
This study suggests 2 molecular pathways underlying CAA, with a larger effect size for the pathway including SFRP1 and APOE protein and C-terminally truncated Aβ before position 40. However, the study is an observational cross-sectional study that limits causal inference from the findings.
Authors
- Shahram Oveisgharan (ORCID: https://orcid.org/0000-0001-6841-4830)
- Shinya Tasaki (ORCID: https://orcid.org/0000-0003-3656-7394)
- Sonal Agrawal (ORCID: https://orcid.org/0000-0003-2375-8888)
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Guanhong Miao (ORCID: https://orcid.org/0000-0002-8083-7032)
- Ricardo A. Vialle (ORCID: https://orcid.org/0000-0003-3311-4197)
- Tracy L. Young‐Pearse (ORCID: https://orcid.org/0000-0001-7846-1542)
- Nicholas T. Seyfried (ORCID: https://orcid.org/0000-0002-4507-624X)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0002-9482-1752)
- Lisa L. Barnes (ORCID: https://orcid.org/0000-0002-0072-9817)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Kátia de Paiva Lopes (ORCID: https://orcid.org/0000-0002-0240-0126)
- Vladislav Petyuk (ORCID: https://orcid.org/0000-0003-4076-151X)
- Jinying Zhao (ORCID: https://orcid.org/0000-0003-3243-2660)
- Jingyun Yang (ORCID: https://orcid.org/0000-0002-3495-3710)
- Lei Yu (ORCID: https://orcid.org/0000-0002-0237-8758)
- Yanling Wang (ORCID: https://orcid.org/0000-0002-8589-4239)
Institutions
- Brigham and Women's Hospital (US)
- Rush University Medical Center (US)
- Pacific Northwest National Laboratory (US)
- Emory University (US)
- Columbia University Irving Medical Center (US)
- University of Florida Health (US)
- University of Florida (US)
- Columbia University (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1212/wnl.0000000000214024
- Citations
- 1
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.39