Changes in Gray Matter Morphology and White Matter Microstructure Across the Adult Lifespan in People With Temporal Lobe Epilepsy

This study highlights that patients with TLE exhibit more pronounced and widespread gray and white matter atrophy across the lifespan. The cross-sectional nature of our study limits definitive conclusions on whether the atrophy shown is progressive but emphasizes the importance of prompt diagnosis and intervention in patients. Collectively, our results motivate future longitudinal studies to clarify consequences of drug-resistant epilepsy.

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Publication Details

Journal
Neurology
Published
2025-08-22
DOI
https://doi.org/10.1212/wnl.0000000000213688
Citations
3
Primary Topic
Epilepsy research and treatment
Type
article
Field-Weighted Citation Impact
4.41
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article

Changes in Gray Matter Morphology and White Matter Microstructure Across the Adult Lifespan in People With Temporal Lobe Epilepsy

Orrin Devinsky, Colin P. Doherty, John S. Duncan, Sarah J. A. Carr et al.
3 citations
Neurology
Epilepsy research and treatment
4.41
article

Changes in Gray Matter Morphology and White Matter Microstructure Across the Adult Lifespan in People With Temporal Lobe Epilepsy

Orrin Devinsky, Colin P. Doherty, John S. Duncan, Sarah J. A. Carr, Boris C. Bernhardt, Raviteja Kotikalapudi, Christian Rummel, Lorenzo Caciagli, Emanuele Bartolini, Matteo Lenge, Renzo Guerrini, Felix von Podewils, Erik Kaestner, Terence John O'Brien, Domenico Tortora, Maria Eugenia Caligiuri, Esmaeil Davoodi‐Bojd, Sophia I. Thomopoulos, Peter N. Taylor, Reetta Kälviäinen, Benoît Caldairou, Stefano Meletti, Pascal Martin, Raúl Rodríguez‐Cruces, Judy Chen, Gavin P. Winston, Dewi Schrader, Manuela Tondelli, Jessica Royer, Patricia Desmond, Ezequiel L. Gleichgerrcht, Mark P. Richardson, Gianpiero L. Cavalleri, Anna Elisabetta Vaudano, Mina Ryten, Fernando Cendes, Bernd Weber, Niels K. Focke, Antonio Gambardella, Sönke Langner, Leonardo Bonilha, Chantal Depondt, Barbara A. K. Kreilkamp, Tobias Bauer, Benjamin Bender, Benjamin Sinclair, Saud Alhusaini, Mariasavina Severino, Julie Absil, Gian Marco Duma, Hamid Soltanian‐Zadeh, Roland Wiest, Sara Larivière, Mira Semmelroch, Rhys Huw Thomas, Mario Mascalchi, Lucy E. Vivash, Eugenio Abela, Luis Concha, Patrick Kwan, Simon S. Keller, Christopher D. Whelan, Sjoerd B. Vos, Carrie R. McDonald, Neda Bernasconi, Alice Ballerini, Sonya Foley, Marian Galovic, Sean N. Hatton, Donatello Arienzo, Graeme D. Jackson, Heath Pardoe, Sanjay M. Sisodiya, Andrea Bernasconi, Marina K. M. Alvim, Martin Domín, Alexander Ngo, Elaine Lui, Angelo Labate, Clarissa Lin Yasuda, Khalid Hamandi, Magdalena Kowalczyk, Paolo Bonanni, Theodor Rüber, Junsong Zhang, Paul M. Thompson, Norman Delanty
article en
3 citations

Abstract

This study highlights that patients with TLE exhibit more pronounced and widespread gray and white matter atrophy across the lifespan. The cross-sectional nature of our study limits definitive conclusions on whether the atrophy shown is progressive but emphasizes the importance of prompt diagnosis and intervention in patients. Collectively, our results motivate future longitudinal studies to clarify consequences of drug-resistant epilepsy.

NeurologyVol. 105(6)
University of Messina (IT), University of Southern California (US), University of Bern (CH), University of Modena and Reggio Emilia (IT), Montreal Neurological Institute and Hospital (CA), The Royal Melbourne Hospital (AU), Université Libre de Bruxelles (BE), Université de Sherbrooke (CA), University of British Columbia (CA), Royal College of Surgeons in Ireland (IE), University of Liverpool (GB), Emory University (US), Henry Ford Health System (US), Autonomous University of Queretaro (MX), The University of Melbourne (AU), University of Eastern Finland (FI), Universidade Estadual de Campinas (UNICAMP) (BR), King's College London (GB), Xiamen University (CN), Queen's University (CA), University of Tehran (IR), Florey Institute of Neuroscience and Mental Health (AU), Brown University (US), Universitätsmedizin Greifswald (DE), University Hospital Bonn (DE), University Hospital of Wales (GB), Istituto Giannina Gaslini (IT), Walton Centre (GB), University of California San Diego (US), Magna Graecia University (IT), Azienda Unita' Sanitaria Locale Di Modena (IT), Monash Alfred Psychiatry Research centre (AU), Circuit Therapeutics (United States) (US), University Hospital of Zurich (CH), Azienda Ospedaliero-Universitaria di Modena (IT), Meyer Children's Hospital (IT), University Children's Hospital Tübingen (DE), Fondazione Stella Maris (IT), Azienda Ospedaliera Universitaria Senese (IT), Hertie Institute for Clinical Brain Research (DE), National Hospital for Neurology and Neurosurgery (GB), IRCCS Eugenio Medea (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), BC Children's Hospital (CA), St. James's Hospital (IE), Epilepsy Foundation (AU), Future Analytics (IE), University of Florence (IT), University College London (GB), Epilepsy Society (GB), McGill University (CA), Monash University (AU), New York University (US), University of Göttingen (DE), Xiamen University of Technology (CN), Cardiff University (GB), University of Tübingen (DE), University of Genoa (IT), Newcastle University (GB), Universidad Nacional Autónoma de México (MX)
Zero hunger
Openalex Percentile: Top 5%
Epilepsy research and treatment
4.41
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