Spatial mapping of rheumatoid arthritis synovial niches reveals a LYVE1+ macrophage network associated with response to therapy
This study provides an unprecedented spatial and dynamic blueprint of the RA synovium's response to therapy. We identify the LYVE1<sup>+</sup> macrophage network as a pivotal component of synovial homeostasis and its restoration as a hallmark of clinical remission. These findings unveil novel cellular and molecular targets, paving the way for more active therapeutic strategies.
Authors
- Julien De Lima (ORCID: https://orcid.org/0000-0002-0191-9479)
- Alessandra Nerviani (ORCID: https://orcid.org/0000-0003-4064-4014)
- Anne‐Sophie Dumé (ORCID: https://orcid.org/0000-0002-9376-2607)
- P. Humbert (ORCID: https://orcid.org/0000-0003-1208-5550)
- Henri‐Alexandre Michaud (ORCID: https://orcid.org/0000-0002-6165-1929)
- Liliane Fossati‐Jimack (ORCID: https://orcid.org/0000-0003-3757-3999)
- Laure-Agnès Chépeaux (ORCID: https://orcid.org/0000-0002-4811-2365)
- Frédéric Blanchard (ORCID: https://orcid.org/0000-0003-1055-2573)
- Florence Apparailly (ORCID: https://orcid.org/0000-0003-1762-084X)
- Jérôme Guicheux (ORCID: https://orcid.org/0000-0003-2754-3024)
- Myles Lewis (ORCID: https://orcid.org/0000-0001-9365-5345)
- Benoît Le Goff (ORCID: https://orcid.org/0000-0002-4540-4549)
- Costantino Pitzalis (ORCID: https://orcid.org/0000-0003-1326-5051)
- Adrien Le Pluart (ORCID: https://orcid.org/0000-0002-4513-6054)
- Marie‐Astrid Boutet (ORCID: https://orcid.org/0000-0002-1519-6902)
- Olivier Bortolotti (ORCID: https://orcid.org/0000-0002-3669-8215)
- Gabriel Courties (ORCID: https://orcid.org/0000-0002-0003-7407)
- Sophie Allain‐Maillet (ORCID: https://orcid.org/0000-0003-2241-5736)
- Yaël Glasson (ORCID: https://orcid.org/0000-0002-5072-7078)
- Rachel Lau (ORCID: https://orcid.org/0000-0002-8330-8048)
Institutions
- Humanitas University (IT)
- Inserm (FR)
- Queen Mary University of London (GB)
- Université de Montpellier (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Institute for Regenerative Medicine & Biotherapy (FR)
- Institut de Recherche en Cancérologie de Montpellier (FR)
- William Harvey Research Institute (GB)
- Nantes Université (FR)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.ard.2025.07.019
- Citations
- 8
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 13.34
Funders
- Infrastructures en Biologie Santé et Agronomie
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique