Mechanism of NOTCH2 in promoting intrahepatic bile duct development
In conclusion, the activation of the Notch signaling pathway leads to increased NOTCH2 expression, which promotes the differentiation of hepatoblasts into intrahepatic cholangiocytes and the development of intrahepatic bile ducts during embryonic stages in C57BL/6CrSlc mice. The results of this study may provide a theoretical basis for infantile intrahepatic cholestasis treatment.
Authors
- Shengxuan Liu (ORCID: https://orcid.org/0009-0004-6466-3230)
- Biao Zou (ORCID: https://orcid.org/0009-0002-7674-7138)
- Benping Zhang (ORCID: https://orcid.org/0000-0001-9107-6833)
- Chen Dong (ORCID: https://orcid.org/0000-0002-9169-3919)
- Sainan Shu
Institutions
- Tongji Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1186/s12876-025-04217-y
- Primary Topic
- Pediatric Hepatobiliary Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00