The role of amino acid composition in the antibacterial activity of laterosporulin analogs
Crystal structures of three different laterosporulins isolated from various strains of Brevibacillus were compared to understand the structure/function relationship. Results obtained in this study suggest that subtle variations in the amino acid composition of laterosporulins, distribution, and surface accessibility of charged residues can profoundly affect their antimicrobial activity.
Authors
- Suresh Korpole (ORCID: https://orcid.org/0000-0001-5702-2380)
- Krishan Gopal Thakur (ORCID: https://orcid.org/0000-0003-4500-2133)
- Nayudu Nallabelli
- Vipul Solanki (ORCID: https://orcid.org/0000-0003-0354-9296)
- Sumeeta Kumari (ORCID: https://orcid.org/0000-0001-9572-8093)
- Pushpanjali Bhardwaj
- Vishakha Grover (ORCID: https://orcid.org/0000-0001-7492-0676)
- Piyush Baindara (ORCID: https://orcid.org/0000-0001-5620-633X)
- Shelley Sardul Singh (ORCID: https://orcid.org/0009-0008-0806-8196)
Institutions
- Institute of Microbial Technology (IN)
- Panjab University (IN)
Publication Details
- Journal
- Journal of Applied Microbiology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1093/jambio/lxaf208
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00