Basophil-derived exosomes exacerbate systemic lupus erythematosus by regulating B-cell proliferation via miR-24550
Basophil-derived exosomal miR-24550 promotes B-cell proliferation and activation by targeting KLF5, thereby exacerbating SLE progression. This study presents a novel strategy for SLE prevention and treatment.
Authors
- Fengbiao Guo (ORCID: https://orcid.org/0000-0003-1953-5083)
- Xiaowei Xu (ORCID: https://orcid.org/0000-0002-8629-4438)
- Lixin You (ORCID: https://orcid.org/0000-0002-0743-8676)
- Lawei Yang
- Qingjun Pan (ORCID: https://orcid.org/0000-0002-8060-9099)
- Hua-feng Liu (ORCID: https://orcid.org/0000-0002-5177-0334)
- Bevan E. Huang (ORCID: https://orcid.org/0000-0002-1981-5838)
- Jiaqi Lun
- Xing Lü (ORCID: https://orcid.org/0000-0002-2796-4390)
- Shuzhen Liao
- Jiaxuan Chen (ORCID: https://orcid.org/0000-0003-3283-3085)
- Xiaoxian Liu (ORCID: https://orcid.org/0009-0008-1434-5727)
- Haiyan Xiao (ORCID: https://orcid.org/0000-0003-2878-337X)
Institutions
- Guangdong Medical College (CN)
- Augusta University (US)
- Discovery Institute (US)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1186/s12916-025-04324-3
- Citations
- 1
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- National Natural Science Foundation of China