Evaluation of Mayeen Kalan (Tamarix dioica) through phytochemical, pharmacognostical, and pharmacological studies from an ethnomedicinal perspective in Unani medicine

Objective: This study seeks to provide an in-depth review and compilation of critical information regarding the botanical description, pharmacognostic characteristics, phytochemical constituents, pharmacological activities, and ethnomedicinal uses of Tamarix dioica, commonly known as Mayeen Kalan. The aim is to establish its significant therapeutic potential within the framework of Unani medicine. Methods: We meticulously gathered data from esteemed classical Unani texts alongside contemporary scientific literature. This analysis encompassed botanical descriptions, traditional applications, and pharmacological investigations to highlight the plant’s key therapeutic actions and pharmacological properties. Results: Tamarix dioica, a prominent shrub from the Tamaricaceae family, is increasingly recognized in Unani medicine for its diverse benefits, including its Constipative (Qabiz), retentive (Habis), Anti-inflammatory, Astringent, Antifungal, Antibacterial, Hepatoprotective, and Antipyretic properties. Rigorous phytochemical screening revealed a wealth of active compounds, such as flavonoids, phenols, saponins, tannins, steroids, and terpenoids. Pharmacological studies provided compelling evidence of its antidiarrheal, hepatoprotective, antipyretic, antihyperlipidemic, and antimicrobial effects, showcasing significant dose-dependent outcomes that firmly support its traditional claims. Conclusion: Tamarix dioica stands out as a powerful botanical with a remarkable array of pharmacological activities that validate its traditional uses in Unani medicine, particularly as an astringent and hepatoprotective agent. To harness its full potential, further clinical and toxicological studies are essential for developing safe and effective therapeutic formulations suitable for both modern and traditional medical practices. This research not only underscores the plant's historical importance but also paves the way for its integration into contemporary healthcare solutions. Keywords: Tamarix dioica; Mayeen Kalan; traditional medicine; hepatoprotective; antidiarrheal; antimicrobial activity, Aspergillus flavis, Microsporum canis