Formulation and Evaluation of Nanogel Containing Silver Nanoparticle of Phytoconstituent of Lantana camara for Topical Delivery

The present study focuses on the formulation and evaluation of a nanogel incorporating silver nanoparticles (AgNPs) synthesized using the ethanolic extract of Lantana camara leaves for topical delivery. Initial pharmacognostical and phytochemical investigations confirmed the presence of bioactive compounds such as flavonoids, tannins, and terpenoids, indicating therapeutic potential. Silver nanoparticles were synthesized via a green route and characterized using UV-Vis spectroscopy, FTIR, SEM, and TEM, confirming their spherical morphology and antioxidant efficacy. The AgNPs were then incorporated into Carbopol-based nanogel formulations. Five batches (F1–F5) were developed and evaluated for physicochemical properties, drug content, in vitro release, and antibacterial activity. Among these, batch F3 exhibited optimal pH (6.1), viscosity (8600 cps), drug content (98.5%), and sustained drug release (87.6% over 8 hours), along with the highest antibacterial activity (21.5 mm zone of inhibition). The study concludes that the formulated nanogel, especially batch F3, holds significant potential for topical applications due to its antimicrobial, antioxidant, and controlled drug delivery properties. Keywords: Lantana camara, Silver Nanoparticles, Nanogel, Topical Delivery, Antibacterial Activity, Antioxidant, Phytoconstituents, Green Synthesis, Drug Release.