Novel strategies for inhibiting SufA protease: the role of ester substituents and biological properties
1-AAP derivatives, particularly 8a and 8c, exhibit promising antibacterial properties. These findings validate SufA as a therapeutic target and support further development of peptide-based inhibitors to enhance efficacy and selectivity.
Authors
- Ewa Burchacka (ORCID: https://orcid.org/0000-0003-2177-1800)
- Katarzyna Pstrowska (ORCID: https://orcid.org/0000-0003-2082-4624)
- Gabriela Cieniuch
- Paweł Pięta (ORCID: https://orcid.org/0000-0003-3874-6740)
- Michał Jewgiński (ORCID: https://orcid.org/0000-0003-4931-5452)
- Agnieszka Korzenowska-Kowal
Institutions
- University of Science and Technology (YE)
- Wrocław University of Science and Technology (PL)
- Poznan University of Medical Sciences (PL)
- Ludwik Hirszfeld Institute of Immunology and Experimental Therapy (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2025-08-03
- DOI
- https://doi.org/10.1080/17568919.2025.2545173
- Primary Topic
- Protein Interaction Studies and Fluorescence Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Narodowe Centrum Nauki