Pharmacokinetic and biochemical properties of clindamycin compared with imipenem loaded bone cement

Bone cement is consider as a medical material used to anchor implants to bone in orthopedic and surgical procedures. It is commonly made of polymethyl methacrylate (PMMA), a biocompatible substance that provides mechanical stability. The objective of this study is to examine the elution and biomechanical properties of antibiotics- loaded bone cement. The groups of experiment include, Antibiotic-free bone cement and bone cement containing 5%, 10%, 15%, and 1% of imipenen and Clindamycin, respectively. A total of 35 specimens for compression and tensile testing were acquired. The drug concentration-time curve of imipenem (IMP) and clindamycin was constructed after the eluent drug concentration was measured at 24, 48, 72 h, and 6, 12, and 24 days. All bone cement samples surpassed the ISO 5833 standard for compressive strength (minimum 70 MPa). Clindamycin-loaded cements had higher compressive and tensile strength values compared to IMP -loaded and antibiotic-free cements, particularly at 10% and 15% drug concentrations, Clindamycin-loaded bone cement showed superior elution properties, releasing the drug more consistently over 24 days compared to IMP, which had a rapid release in the first 72 hours and a sharp decline afterward. Clindamycin demonstrated greater antibacterial potency against Pseudomonas aeruginosa than IMP, as shown by larger zones of inhibition in agar diffusion assays. Regarder to antibiotic elution, IMP concentrations dropped significantly after 72 hours, while clindamycin maintained a steadier release profile, offering prolonged antibacterial coverage.At the end of 24 days, clindamycin showed a threefold higher cumulative release compared to IMP. In conclusion, Clindamycin-loaded bone cement showed to be more effective than IMP in terms of sustained drug release, mechanical properties, and antibacterial activity, making it a promising choice for treating bone and joint infections.