<i>Keap1</i> Deletion Rescues Cell Death Associated With <i>Gpx4</i> Loss in Hepatocytes During Acute Liver Injury
Our results demonstrate that Gpx4 plays a critical role in ALF as its absence exacerbates apoptosis. Activating Keap1-dependent pathways targeting antioxidant defence systems and upregulating BCL2 provides substantial protection against ALF in mice lacking Gpx4 in hepatocytes. Our findings suggest that the Keap1-Nrf2 axis is a promising therapeutic target in ALF.
Authors
- Mark Kühnel (ORCID: https://orcid.org/0000-0003-3558-2576)
- Nikolaus Gaßler (ORCID: https://orcid.org/0000-0002-7351-258X)
- Chaochao Wang
- Jan Georg Hengstler (ORCID: https://orcid.org/0000-0002-1427-5246)
- Karolina Edlund (ORCID: https://orcid.org/0000-0002-0276-2143)
- Danny Jonigk (ORCID: https://orcid.org/0000-0002-5251-2281)
- Jörg Reinders (ORCID: https://orcid.org/0000-0003-1025-7849)
- Julia Grube (ORCID: https://orcid.org/0000-0002-7225-4582)
- Jana Dietrich (ORCID: https://orcid.org/0000-0001-7211-3168)
- Leticia Colyn (ORCID: https://orcid.org/0000-0002-7403-9149)
- Christian Trautwein
Institutions
- TU Dortmund University (DE)
- German Center for Lung Research (DE)
- Jena University Hospital (DE)
- Leibniz Research Centre for Working Environment and Human Factors (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Liver International
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1111/liv.70210
- Citations
- 4
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Deutsche Forschungsgemeinschaft
- European Association for the Study of the Liver