<i>Gα13</i> Overexpression in the Medial Prefrontal Cortex Disrupts Social Behavior Through the Adcyap1/cAMP/PKA/NMDAR Pathway
These findings suggest that overexpression of Gα13 in the mPFC impairs social behavior by disrupting neuronal function and synaptic plasticity via the Adcyap1/cAMP/PKA/NMDAR pathway. Targeting Gα13 may offer a novel therapeutic strategy for addressing social deficits in SCZ.
Authors
- Kezhi Liu (ORCID: https://orcid.org/0000-0003-4515-4209)
- Kenji Hashimoto (ORCID: https://orcid.org/0000-0002-8892-0439)
- Minglan Yu
- Binglong Wang (ORCID: https://orcid.org/0000-0003-4281-6289)
- Wei Dong (ORCID: https://orcid.org/0000-0002-8151-9407)
- Xiaoqi Geng
- Jin Zhang (ORCID: https://orcid.org/0000-0003-3731-8859)
- Rong Ma (ORCID: https://orcid.org/0009-0009-2060-9853)
- Bo Xiang
- Rui Fan
- Jianlin Pu
- Jianfei Wu (ORCID: https://orcid.org/0009-0006-4191-3000)
- Tingting Wang (ORCID: https://orcid.org/0000-0001-5288-2314)
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Zigong First People's Hospital (CN)
- Center for Forensic Mental Health, Chiba University (JP)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1093/schbul/sbaf131
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology of Sichuan Province
- Luzhou Science and Technology Bureau