“ASSOCIATION OF SERUM HEPATIC ENZYMES WITH METABOLIC SYNDROME AMONG THE NORTH INDIAN POPULATION”

The rise in metabolic syndrome (MetS) worldwide is mainly because of people’s sedentary lifestyles and unhealthy dietary patterns. There is a strong link between MetS and liver problems, which frequently appear as liver inflammation and lead to a higher risk of illness and death. Liver dysfunction is a common sign among people living with MetS, which may show signs of liver injury. The study is designed to examine how metabolic syndrome might contribute to liver injury, and also helps in learning more about the mechanisms involved. Aim:  To find if there is any association between the activity of the Hepatic enzymes and MetS. Material & Methods: This is a hospital-based cross-sectional study in 150 patients diagnosed with MetS. It was explained to all participants, who signed consent before the study started, that we would measure their serum liver enzymes ALT, AST, ALP, and GGT, as well as HDL-C, TG, and FBG in their fasting blood, and that we would measure their waistline and blood pressure. All Biochemical parameters (ALT, AST, ALP, GGT, HDL-C, TG, and FBG) were analysed using a MERCK semi-automated analyser in the department of biochemistry. Anthropometric data such as waist circumference and blood pressure were measured independently using standard clinical procedures. Data was analysed using SPSS version 29, and Pearson’s correlation test was done to check for a link between Metabolic syndrome and serum liver enzymes. For these results, p-values less than 0.05 were considered statistically significant. Results: Significant changes in the concentration of the estimated liver enzymes were observed in the patients having metabolic syndrome. We observed that serum activity of hepatic enzymes (ALT, AST, ALP, and GGT) was not only associated with components of MetS but also exhibited elevated activity when compared to reference values. Conclusion: Liver enzyme activities were found to be raised in people with metabolic syndrome. Monitoring alterations in liver enzymes may provide critical insights into the pathophysiology of metabolic syndrome and guide the development of more effective therapeutic strategies. Knowing about liver parameters not only supports the early detection of liver dysfunction but also makes it easier to find and manage both liver dysfunction and MetS.