Prophylactic Effect of Apigenin Against Bisphenol A-Induced Hepatotoxicity

Background: Bisphenol A (BPA) is the most widely used endocrine disruptor in the world. As the liver is the main organ involved in the detoxification and metabolism of BPA, it is one of the organs most affected by BPA poisoning. No study has investigated the potential effect of apigenin (APG) on BPA-induced hepatotoxicity. This study was conducted to investigate the possible hepatoprotective effects of APG against subacute BPA intoxication in rats. Methods: Twenty-eight rats were randomly divided into 4 groups: (i) control, (ii) BPA (130 mg/kg), (iii) BPA (130 mg/kg) + APG100 (100 mg/kg), and (iv) BPA (130 mg/kg) + APG200 (200 mg/kg). Both BPA and APG were administered daily by gavage for a total of 28 days. At the end of the experiment, all animals were sacrificed and serum liver function parameters, markers of oxidative stress and inflammation in liver tissue, and histopathological analysis of the liver were assessed. Results: Bisphenol A pre-treatment impaired liver function tests, induced oxidative stress and inflammatory response, and disrupted liver microarchitecture. Apigenin pre-treatment improved liver function tests, suppressed oxidative stress and inflammation, and, especially high doses, normalized liver microarchitecture. Conclusion: It is observed that apigenin pre-treatment has a hepatoprotective effect, both biochemical and histological, in eliminating the hepatotoxicity caused by BPA administration.Cite this article as: Berköz, M. Prophylactic effect of apigenin against bisphenol A-induced hepatotoxicity. Trends in Pharmacy,2025, 2, 0006, doi: 10.5152/TrendsPharm.2025.25003.