Radioprotective Potential of Oxy + (Arthrospira): A Natural Shield against Radiation

Background: Exposure to ionizing radiation poses serious health risks, including DNA damage, oxidative stress, and increased cancer susceptibility. Natural radioprotectors are gaining attention due to their safety and efficacy. A natural supply of arthrospira called Oxy+, which is produced in Aruba for lifefactors as a phytotherapeutic agent. Its chief ingredient is spirulina. Spirulina, a blue-green microalga, is rich in antioxidants, vitamins, and proteins, making it a promising candidate for radioprotection. Objective: This review examines the radioprotective potential of Oxy+, focusing on its biochemical composition, mechanisms of action, and therapeutic applications in mitigating radiation-induced damage. Methods: A comprehensive literature review was conducted using databases such as PubMed, Scopus, and Google Scholar. Studies focusing on Oxy+’s antioxidant properties, immunomodulatory effects, and ability to mitigate radiation-induced cellular damage were analyzed. In vivo and in vitro experimental findings were examined to assess its efficacy. Results: Oxy+ demonstrates strong radioprotective properties due to its high content of phycocyanin, β-carotene, and phenolic compounds. These bioactive molecules scavenge free radicals, reducing oxidative stress and DNA damage caused by radiation. Studies indicate that Oxy+ enhances the activity of endogenous antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Additionally, Oxy+ modulates immune responses by promoting cytokine production and reducing inflammation. Animal studies suggest that Oxy+ supplementation improves survival rates and mitigates radiation-induced hematopoietic and gastrointestinal injuries. Conclusion: Oxy+ exhibits significant potential as a natural radioprotector due to its antioxidant, immunomodulatory, and anti-inflammatory properties. Further clinical studies are necessary to validate its efficacy in humans and optimize dosage recommendations. Oxy+ could be a valuable adjunct in radiation therapy, space missions, and nuclear exposure scenarios. Keywords: Oxy+; Spirulina, Radioprotection; DNA Damage, Immunomodulation, Radiation Therapy