Inhibition of Mettl3-mediated m6A RNA modification of HMGCS1 protects retinal ganglion cells from glutamate excitotoxicity-induced ferroptosis in a rat model of glaucoma
Our study investigates the inhibition of Mettl3-mediated m6A RNA modification of HMGCS1 as a critical regulator of RGC ferroptosis in glaucoma, providing a potential therapeutic target for glaucoma.
Authors
- Weizhou Fang (ORCID: https://orcid.org/0000-0002-6799-9301)
- Zhaohua Xia
- Wulong Zhang
- Xiaobo Xia (ORCID: https://orcid.org/0000-0002-2785-3391)
- Lemeng Feng
- Weitao Song
- Chao Wang (ORCID: https://orcid.org/0000-0001-6425-7145)
- Cheng Zhang (ORCID: https://orcid.org/0000-0002-6642-475X)
- Weiming Zhu (ORCID: https://orcid.org/0000-0002-8491-156X)
- Ye He (ORCID: https://orcid.org/0000-0002-3156-7064)
Institutions
- Central South University (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- Hunan University (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1097/js9.0000000000003213
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61