Open field test in rats v1

Protocol for performing the open field test in rats. The open field test measures spontaneous locomotion during 5-min free exploration of an open field arena (1m x 1m), and can be used to measure hypolocomotion in animal models of Parkinson's disease. Rats with decreased nigrostriatal dopaminergic neurotransmission show decreased mobility during the open field test.

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Published
2025-06-24
DOI
https://doi.org/10.17504/protocols.io.rm7vzqw78vx1/v1
Primary Topic
Animal testing and alternatives
Type
article
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article

Open field test in rats v1

Eduard Bentea, María Sanchiz Calvo, Veerle Baekelandt
Animal testing and alternatives
article

Open field test in rats v1

Eduard Bentea, María Sanchiz Calvo, Veerle Baekelandt
article en

Abstract

Protocol for performing the open field test in rats. The open field test measures spontaneous locomotion during 5-min free exploration of an open field arena (1m x 1m), and can be used to measure hypolocomotion in animal models of Parkinson's disease. Rats with decreased nigrostriatal dopaminergic neurotransmission show decreased mobility during the open field test.

KU Leuven (BE)
Openalex Percentile: Top 76%
Animal testing and alternatives
DOIOpen Access PDFOpenAlex
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Open field test in rats v1 — Eduard Bentea, María Sanchiz Calvo, et al. · (2025) | TGRS Research Map | TGRS