World's First Human Case of Significant Dupuytren's Contracture Resolution Two Years Post Single Platelet-Rich Plasma Injection

Dupuytren’s contracture is a progressive fibroproliferative condition affecting the palmar fascia, often leading to hand dysfunction. Management ranges from conservative observation to corticosteroid or collagenase injections and ultimately surgery for advanced stages. This case presents the world’s first documented human report of a middle-aged woman with early-stage Dupuytren’s contracture who demonstrated significant and sustained resolution two years after a single ultrasound-guided injection of autologous Platelet-Rich Plasma (PRP). The patient had previously undergone surgical fasciectomy on the contralateral hand with residual numbness. PRP was injected directly into the pathological cords under local anaesthesia. At nine months post-injection, near-complete functional recovery was noted and at the two-year mark, the patient remained symptom-free without recurrence. This case introduces PRP as a novel, non-surgical, regenerative option for early Dupuytren’s disease, warranting further investigation in controlled clinical studies.