A Snapshot Of Flavin-Conjugated Pt Anticancer Agents: Pt(IV)-To-Pt(II) Reduction Revealed By X-Ray Fluorescence Imaging And XANES
Synchrotron-based X-ray spectromicroscopy reveals enhanced cellular uptake and remarkably fast, efficient photoactivation of Pt(IV) prodrugs bearing flavin groups. These features correlate with superior anticancer activity compared to non-conjugated analogues, highlighting the potential of flavin-functionalised Pt(IV) complexes as candidates for photoactivated chemotherapy (PACT).
Authors
- Juan Sánchez-Camacho (ORCID: https://orcid.org/0000-0002-1112-3589)
- Carlos Sánchez-Cano (ORCID: https://orcid.org/0000-0002-9522-0019)
- Jessica M. Walker (ORCID: https://orcid.org/0000-0001-7218-9138)
- Luca Salassa (ORCID: https://orcid.org/0000-0002-2112-9095)
- Esteban Zingales
Institutions
- Ikerbasque (ES)
- University of the Basque Country (ES)
- Diamond Light Source (GB)
- CIC biomaGUNE (ES)
- Donostia International Physics Center (ES)
Publication Details
- Journal
- ChemRxiv
- Published
- 2025-08-14
- DOI
- https://doi.org/10.26434/chemrxiv-2025-chsfq
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Diamond Light Source
- Eusko Jaurlaritza
- Euskal Herriko Unibertsitatea
- European Regional Development Fund
- Agencia Estatal de Investigación