SHP2 inhibition by SHP099 attenuates IL-6–driven osteoclastogenesis in growth plate injury
Our findings underscore the pivotal role of SHP2 as a downstream signaling molecule of IL-6 in mediating inflammatory responses during bone repair, suggesting that SHP2 inhibition may present a novel therapeutic approach to prevent pathological bone remodeling and enhance recovery following growth plate injuries. Future investigations should focus on the translational potential of SHP2 inhibitors in pediatric orthopedics.
Authors
- Hai Li
- Jing Ding (ORCID: https://orcid.org/0000-0001-9892-1657)
- Zhen‐Zhen Dai
- Ning Li (ORCID: https://orcid.org/0000-0002-2650-363X)
- Qin Zhang (ORCID: https://orcid.org/0000-0002-9845-4099)
- Xiaoman Liu (ORCID: https://orcid.org/0000-0002-8978-5937)
- Lin Sha
Institutions
- Bengbu Medical College (CN)
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1659230
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China