Expression levels of T cell-related immune factors and their correlation with thyroid function in Graves’ disease with varied serum iodine status: insights into immunopathogenesis

1. Serum cytokine levels (including IL-6, IL-9, IL-17A, IL-17F, and IL-22) exhibited significant differences between healthy subjects and patients with newly diagnosed hyperthyroid Graves' disease (GD) under varying serum iodine concentration (SIC). 2. In newly diagnosed hyperthyroid GD patients, serum IL-6 demonstrated positive correlations with SIC, TRAb, and IL-17A (all P < 0.05), while IL-17A showed positive correlations with SIC and IL-6 (P < 0.05). 3. In GD patients with elevated SIC, cytokines IL-17A and IL-6 may contribute to pathogenic processes in hyperthyroid GD.