An exploratory single-cell analysis of peripheral blood mononuclear cells from vedolizumab-treated Crohn’s disease patients identifies response-associated differences among the plasmacytoid dendritic cells and classical monocytes
Non-response to VDZ during treatment is associated with differences in abundance and expression among T and myeloid cells.
Authors
- Jan Verhoeff (ORCID: https://orcid.org/0000-0003-0648-0642)
- Marcel M. A. M. Mannens (ORCID: https://orcid.org/0000-0001-7137-119X)
- Wouter J. de Jonge (ORCID: https://orcid.org/0000-0002-3241-1547)
- Manon de Krijger (ORCID: https://orcid.org/0000-0001-9655-5382)
- Alex Adams (ORCID: https://orcid.org/0000-0001-9364-8540)
- Manon E. Wildenberg (ORCID: https://orcid.org/0000-0003-0671-818X)
- Iris Admiraal (ORCID: https://orcid.org/0000-0003-3335-4924)
- Ishtu Hageman (ORCID: https://orcid.org/0000-0002-3180-156X)
- Jack Satsangi (ORCID: https://orcid.org/0000-0002-6357-9684)
- V Joustra (ORCID: https://orcid.org/0000-0003-4157-7220)
- Geert D’Haens (ORCID: https://orcid.org/0000-0003-2784-4046)
- Peter Henneman (ORCID: https://orcid.org/0000-0003-2179-7808)
- Mohammed Ghiboub (ORCID: https://orcid.org/0000-0002-2095-371X)
- Marja E. Jakobs (ORCID: https://orcid.org/0000-0001-6163-4881)
- Andrew Y. F. Li Yim (ORCID: https://orcid.org/0000-0002-0754-0953)
- Caroline Verseijden (ORCID: https://orcid.org/0009-0001-9284-5734)
- Evgeni Levin (ORCID: https://orcid.org/0000-0002-0368-6146)
- Ahmed M I Elfiky
- Susan Kenter
Institutions
- University of Bonn (DE)
- Dutch Cancer Society (NL)
- John Radcliffe Hospital (GB)
- University Medical Center Utrecht (NL)
- Emma Kinderziekenhuis (NL)
- Amsterdam University Medical Centers (NL)
- Center for Human Reproduction (US)
- Institute of Infection and Immunity (CA)
- University of Amsterdam (NL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1551017
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Leona M. and Harry B. Helmsley Charitable Trust
- Crohn's and Colitis Foundation
- Health~Holland
- Universiteit van Amsterdam