Broad-spectrum antitumor analysis of the telomerase activity inhibitor TPCH derived from the human constitutively expressed protein LPTS/PinX1
The TPCH protein strongly inhibited telomerase activity and suppressed the growth of all tested human telomerase-positive cancer cell lines <i>in vitro</i> and <i>in vivo</i>. Therefore, it could be developed as a broad-spectrum anticancer agent with low toxicity.
Authors
- Ming‐Hui Zhao (ORCID: https://orcid.org/0000-0003-3340-3108)
- Yao Wang (ORCID: https://orcid.org/0000-0003-4174-755X)
- Lingling Wang (ORCID: https://orcid.org/0000-0003-0272-2974)
- Hu Chen (ORCID: https://orcid.org/0000-0001-5472-7158)
- Hui Zhang (ORCID: https://orcid.org/0000-0002-9699-0138)
- Ting Zhang (ORCID: https://orcid.org/0000-0002-6100-8327)
- Guangming Chen (ORCID: https://orcid.org/0000-0002-5353-2655)
- Xiaoying Zhang (ORCID: https://orcid.org/0000-0003-2576-0148)
- Mujun Zhao
- Hongchang Zhou (ORCID: https://orcid.org/0000-0002-8631-3272)
- Yongqiang Wu (ORCID: https://orcid.org/0009-0004-3267-2175)
- D.J. You
- Anqi Li
Institutions
- Huzhou Normal University (CN)
- Beijing VDJBio (China) (CN)
- Center for Excellence in Molecular Cell Science (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3389/fonc.2025.1643155
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00