Effects of Clonapure<sup>®</sup> Supplementation on Intermittent Aerobic Capacity and Explosive Power in Elite Female Volleyball Players

<i>Background: </i>Creatine supplementation has long been established as a performance-enhancing strategy in power and strength-based sports. However, evidence in elite female athletes and in volleyball-specific contexts remains limited. Clonapure<sup>®</sup> is a novel creatine formulation containing creatine monohydrate, creatine phosphate, and phosphate, designed to optimize cellular uptake and metabolic synergy. <i>Methods: </i>In this randomized, double-blind, placebo-controlled pilot trial, 16 elite female volleyball players were randomized to receive either Clonapure<sup>®</sup> or placebo over 28 days. Performance was assessed at three timepoints: T0 (Day 1), T1 (Day 7), and T2 (Day 28). Primary outcomes included the Volleyball Intermittent Endurance Test (VIET), Intermittent Vertical Jump Test (IVJT), and Continuous Vertical Jump Test (CVJT). Quality indicators such as jump count and jump height were also recorded. <i>Results: </i>No adverse events or dropouts were reported. At T2, the Clonapure<sup>®</sup> group showed significantly improved aerobic endurance, with greater total distance covered in the VIET compared to placebo (p<0.001). In the IVJT, the Clonapure<sup>®</sup> group demonstrated early and sustained improvements in peak power (PP), mean power (MP), and fatigue index (FI), with statistical significance achieved for all variables by T2 (PP: p = 0.023; MP: p = 0.026; FI: p = 0.002). The CVJT revealed a similar trend, with significant enhancements in MP and FI at T2. Vertical jump quality indicators (NVJ60sec and VJ60sec) also showed significant improvements in the Clonapure<sup>®</sup> group across T1 and T2. NVJ15sec remained unchanged, while VJ15sec showed mild but consistent gains. <i>Conclusion: </i>Clonapure<sup>®</sup> supplementation over 28 days significantly enhanced both sport-specific endurance and neuromuscular performance in elite female volleyball players. These effects likely reflect improved phosphocreatine resynthesis, enhanced buffering capacity, and superior maintenance of explosive output during repeated high-intensity efforts. The findings support Clonapure<sup>®</sup> as a safe and effective ergogenic aid in elite-level, intermittent sport contexts such as volleyball.