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The catalytic hairpin assembly (CHA) amplification strategy has been widely used for highly sensitive detection of miRNAs. In this study, we developed a controllable linear DNA nanomotor (CLDN) based on H1 and H2 to distinguish homogeneous miRNA sequences with single‐nucleotide differences. This image depicted a thread in the hands of a textile lady symbolically representing the two probes. When target miRNAs trigger the CHA reaction between H1 and H2, the nanomotor is rapidly activated through the simultaneous opening of all self‐quenched H1 hairpins. By adjusting the reaction time and sequence spacing, the assembly valency and probes distance were controlled, thereby enhancing target recognition efficiency. CLDNs show great potential for the quantitative analysis of multiple miRNAs in clinical diagnostics. More details are discussed in the article by Zhu et al . on pages 2359—2366. image