Specific genomic alterations and aggressive clinical features of sporadic thyroid carcinomas in children and adolescents: findings from an in-house cohort study
TCCAs exhibit more aggressive and invasive clinical manifestations than TCAs, particularly in cases with <i>RET</i> fusions or <i>BRAF<sup>V600E</sup></i> coexisting with other point mutations. Targeted comprehensive molecular profiling may aid in the diagnosis and treatment of TCCA.
Authors
- Ying Xu (ORCID: https://orcid.org/0009-0004-6539-4431)
- Ting Wu (ORCID: https://orcid.org/0009-0002-4931-2251)
- Yuguo Wang (ORCID: https://orcid.org/0000-0003-2407-8112)
- Tengxu Zhang (ORCID: https://orcid.org/0000-0002-6194-9661)
- Yongzhen Ren (ORCID: https://orcid.org/0000-0002-6342-5984)
- Zong‐Wan Mao (ORCID: https://orcid.org/0000-0001-7131-1154)
- Gaolei Jia
- Xian Wang (ORCID: https://orcid.org/0000-0002-5950-2545)
- Xinping Wu (ORCID: https://orcid.org/0000-0002-6330-1615)
- Shengsheng Ou
- Feiju Xu
- Guoliang Zhang (ORCID: https://orcid.org/0000-0002-1337-9238)
- Hui Wang (ORCID: https://orcid.org/0000-0002-0045-8797)
- Xiuying Li (ORCID: https://orcid.org/0000-0001-5625-7591)
- Gongxun Tan
- Xiaoqin Qian (ORCID: https://orcid.org/0009-0008-7962-9448)
- Chunhe Shi (ORCID: https://orcid.org/0000-0002-3722-2008)
- Xi Wei
- Qian Ping Gu (ORCID: https://orcid.org/0009-0008-6605-8615)
Institutions
- Jiangsu University (CN)
- Xuzhou Medical College (CN)
- Nantong University (CN)
- Nanjing Traditional Chinese Medicine Hospital (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Yancheng First People's Hospital (CN)
- Yancheng Third People's Hospital (CN)
- Yancheng Second People's Hospital (CN)
- Xuzhou Central Hospital (CN)
- Northern Jiangsu People's Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3389/fendo.2025.1603571
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Jiangsu University
- Government of Jiangsu Province
- Xuzhou Medical University