Head-to-Tail Selective [2 + 2 + 2] Cycloadditions of Bisallenes Enabled by Ligand-Free Nickel(0)
A ligand-free Ni(0) catalyst enables highly chemo- and regioselective [2 + 2 + 2] cycloadditions between 1,5-bisallenes and acetylenes, affording 6,6-fused hexahydroisoquinoline frameworks under mild conditions. DFT studies reveal that head-to-tail selectivity arises from competing oxidative cyclization pathways with metallacycle geometry dictating product formation. This work highlights how simple nickel complexes can achieve precise molecular construction without the need for ancillary ligands.
Authors
- Anna Roglans (ORCID: https://orcid.org/0000-0002-7943-5706)
- Stuart C. D. Kennington (ORCID: https://orcid.org/0000-0001-6804-7794)
- Arijit Saha (ORCID: https://orcid.org/0000-0003-1354-814X)
- Anna Pla‐Quintana (ORCID: https://orcid.org/0000-0003-2545-9048)
- Roger Monreal‐Corona (ORCID: https://orcid.org/0000-0003-3071-9887)
- Mou Mandal (ORCID: https://orcid.org/0000-0002-9026-6907)
- Albert Poater (ORCID: https://orcid.org/0000-0002-8997-2599)
Institutions
- Universitat de Girona (ES)
Publication Details
- Journal
- ACS Catalysis
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1021/acscatal.5c04046
- Citations
- 1
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Universitat de Girona
- Ministerio de Ciencia, Innovación y Universidades
- Agència de Gestió d'Ajuts Universitaris i de Recerca