Linoleic acid drives pulmonary lymphoepithelioma-like carcinoma progression via PPAR-α/TF axis
This study reveals that LA remodels the pLELC tumor microenvironment through the PPAR-α/TF axis, suggesting TF as a potential therapeutic target for pLELC.
Authors
- Baishen Zhang (ORCID: https://orcid.org/0000-0002-9222-4882)
- Zhuoyan Chen (ORCID: https://orcid.org/0000-0003-0766-569X)
- Jiani Zhang (ORCID: https://orcid.org/0000-0002-3211-3830)
- Zhe Wang (ORCID: https://orcid.org/0000-0003-4102-1353)
- Hehong Bao
- Hejing Bao (ORCID: https://orcid.org/0000-0002-6090-9844)
- Yuhuan Wang (ORCID: https://orcid.org/0000-0002-7487-1402)
- Ting Jiang (ORCID: https://orcid.org/0009-0000-9929-3429)
- Wen Zeng (ORCID: https://orcid.org/0000-0003-2471-3235)
- Zhiting Chen (ORCID: https://orcid.org/0000-0003-1495-4772)
- Shudong Ma
Institutions
- Sun Yat-sen University (CN)
- Panyu Hospital of Chinese Medicine (CN)
- Ganzhou People's Hospital (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Gannan Medical University (CN)
- Panyu District Central Hospital (CN)
- Chongqing Three Gorges Central Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3389/fonc.2025.1640201
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00