Heliox preconditioning exerts pulmonary protection effects on neonatal acute respiratory distress syndrome by inhibiting oxidative stress and apoptosis
HePC may attenuate oxidative stress through CaMKII and alleviate cytoplasmic Ca<sup>2+</sup> overload by regulating CaMKII/RyR2, which inhibits apoptosis, exerting lung protection against ARDS.
Authors
- Yuan Shi (ORCID: https://orcid.org/0000-0002-4745-8532)
- Lei Shen (ORCID: https://orcid.org/0009-0004-7705-0126)
- Juan Ma (ORCID: https://orcid.org/0000-0002-2530-2043)
Institutions
- Army Medical University (CN)
- Southwest Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3389/fphar.2025.1621190
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wu Jieping Medical Foundation