Menthol–thymol NADES as a fungicidal and chemosensitizing agent against multidrug-resistant Candida albicans: ROS induction, efflux pump inhibition, and synergy with fluconazole
These findings underscore the therapeutic potential of menthol-thymol NADES as a multifunctional, plant-derived antifungal strategy capable of overcoming multidrug resistance mechanisms and potentiating azole efficacy in <i>C. albicans</i>.
Authors
- Marı́a Gabriela Ortega (ORCID: https://orcid.org/0000-0002-2400-9099)
- Pamela Soledad Bustos (ORCID: https://orcid.org/0000-0003-1521-9585)
- Javier Echeverría (ORCID: https://orcid.org/0000-0002-1688-968X)
- Mariana Andrea Peralta (ORCID: https://orcid.org/0000-0001-9362-8566)
- María Fernanda Silva (ORCID: https://orcid.org/0000-0003-0370-329X)
- Melisa Fabiana Negro (ORCID: https://orcid.org/0009-0008-8145-4739)
- Lautaro Bellezze
Institutions
- Universidad de Santiago de Chile (CL)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad Nacional de Córdoba (AR)
- Instituto de Biología Agrícola de Mendoza (AR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3389/fphar.2025.1643472
- Citations
- 4
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Universidad Nacional de Córdoba
- Consejo Nacional de Investigaciones Científicas y Técnicas