Case Report: Syndrome of inappropriate antidiuretic hormone secretion induced by pramipexole: a case report and literature review

Pramipexole, a novel dopamine receptor agonist, is widely used in the treatment of Parkinson's disease and related syndromes. While studies have demonstrated that pramipexole can cause various adverse reactions, primarily involving the central nervous system or gastrointestinal symptoms, there remains limited reporting on pramipexole-induced syndrome of inappropriate antidiuretic hormone secretion (SIADH). This article analyzes and discusses a case of pramipexole-induced SIADH that occurred in our hospital. At the same time, we also summarize and discuss all current cases of pramipexole-induced SIADH. We anticipate these findings will serve as a valuable clinical reference to guide appropriate medication use.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2025-08-15
DOI
https://doi.org/10.3389/fphar.2025.1627245
Primary Topic
Glycogen Storage Diseases and Myoclonus
Type
article
Field-Weighted Citation Impact
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article

Case Report: Syndrome of inappropriate antidiuretic hormone secretion induced by pramipexole: a case report and literature review

Ke-Qian Chen, Xiang Liu, Haibo Lei
Frontiers in Pharmacology
Glycogen Storage Diseases and Myoclonus
article

Case Report: Syndrome of inappropriate antidiuretic hormone secretion induced by pramipexole: a case report and literature review

Ke-Qian Chen, Xiang Liu, Haibo Lei
article en

Abstract

Pramipexole, a novel dopamine receptor agonist, is widely used in the treatment of Parkinson's disease and related syndromes. While studies have demonstrated that pramipexole can cause various adverse reactions, primarily involving the central nervous system or gastrointestinal symptoms, there remains limited reporting on pramipexole-induced syndrome of inappropriate antidiuretic hormone secretion (SIADH). This article analyzes and discusses a case of pramipexole-induced SIADH that occurred in our hospital. At the same time, we also summarize and discuss all current cases of pramipexole-induced SIADH. We anticipate these findings will serve as a valuable clinical reference to guide appropriate medication use.

Frontiers in PharmacologyVol. 16
Hunan University (CN), Xiangyang Central Hospital (CN)
Openalex Percentile: Top 67%
Glycogen Storage Diseases and Myoclonus
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