Comparative analysis of CDR3 length-dependent patterns in VHHs
These findings highlight the significant impact of CDR3 length on VHH sequence, structure, and antigen interaction characteristics, providing valuable insights for VHH engineering, synthetic library design, and the development of therapeutic nanobodies optimized for targeting diverse epitopes.
Authors
- Tianyu Yang (ORCID: https://orcid.org/0000-0001-9845-637X)
- Wenfeng Xu (ORCID: https://orcid.org/0000-0003-4931-5698)
- Weimin Zhu (ORCID: https://orcid.org/0000-0002-2420-0731)
- Jiahui Yan (ORCID: https://orcid.org/0000-0003-1593-460X)
- Jiaguo Li (ORCID: https://orcid.org/0000-0001-8617-3284)
- Yao Zhang (ORCID: https://orcid.org/0009-0001-0229-9398)
- Lu Zhang (ORCID: https://orcid.org/0000-0001-9049-8807)
- Xinhao Wang (ORCID: https://orcid.org/0009-0002-5639-9914)
Institutions
- Vyne Therapeutics (United States) (US)
- Shanghai Cell Therapy Research Institute (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1647230
- Citations
- 2
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 2.72