Vibrio cholerae-specific antibodies in plasma and saliva in cholera patients during a severe outbreak in Zambia: an antibody profiling approach
We demonstrate that saliva is a viable, non-invasive alternative for cholera antibody-based profiling, offering practical advantages in resource-constrained settings. Given its strong correlation with systemic antibody profiles, saliva may be a practical sample for sero-surveillance in resource-limited settings. Future studies should investigate the duration of these salivary responses to further substantiate their use in estimating disease burden and immunity.
Authors
- Caroline Cleopatra Chisenga (ORCID: https://orcid.org/0000-0002-7850-7915)
- Richelle C. Charles (ORCID: https://orcid.org/0000-0002-8881-1849)
- Julia A. Zhiteneva
- Edward Thomas Ryan (ORCID: https://orcid.org/0009-0005-0169-394X)
- Samuel Bosomprah (ORCID: https://orcid.org/0000-0002-2826-3887)
- Harriet Ng’ombe (ORCID: https://orcid.org/0000-0002-3601-0660)
- Fraser Liswaniso (ORCID: https://orcid.org/0000-0002-7257-9491)
- Biana Bernshtein (ORCID: https://orcid.org/0000-0002-7957-2575)
- Jason B. Harris (ORCID: https://orcid.org/0000-0003-3642-5126)
- David Sack
Institutions
- Centre for Infectious Disease Research in Zambia (ZM)
- Harvard University (US)
- University of Ghana (GH)
- Johns Hopkins University (US)
- Ragon Institute of MGH, MIT and Harvard (US)
- Massachusetts General Hospital (US)
- Amsterdam Institute for Global Health and Development (NL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1641319
- Primary Topic
- Vibrio bacteria research studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00