Association of Microsatellite Instability with Pro-inflammatory Markers and Survival in Patients with Endometrial Cancer

Objective: Endometrial cancer is the most common gynaecological cancer and the fourth most common malignancy after breast, lung and colorectal cancer in developed countries.The aim of this study was to investigate the relationship between microsatellite status and simple pro-inflammatory markers and their effect on survival outcomes in patients diagnosed with endometrial cancer. Material and Methods:We retrospectively reviewed patients with a pathological diagnosis of endometrial cancer who were referred to our clinic between March 2019 and December 2023.Of these patients, 165 were included in our study. Results:In patients with endometrium cancer, 114 patients had microsatellite stable (MSS) tumors, while mismatch repair deficient (dMMR) tumors were present in 30.91% of the entire cohort.No statistically significant difference was observed between the microsatellite groups according to serum inflammatory markers.When the survival of MSS and dMMR patients was analysed, no statistically significant difference was observed between both groups (p=0.875). Conclusion:Our study found a higher rate of endometrioid subtype in dMMR tumours.There was no correlation between microsatellite status and serum inflammatory markers.Microsatellite status was not found to be associated with survival in endometrial cancer.