Ouabain alleviates Mycobacterium abscessus-triggered inflammatory responses through dual regulation of NLRP3 inflammasome activity and M1 macrophage polarization
These findings indicate that ouabain mitigates <i>M. abscessus</i>-induced pulmonary inflammation through dual mechanisms: suppression of NLRP3 inflammasome activation and modulation of M1 macrophage polarization. This study highlights ouabain's potential as a therapeutic candidate for <i>M. abscessus</i> infections.
Authors
- Rongchang Chen (ORCID: https://orcid.org/0000-0002-2396-3702)
- Chen Qiu (ORCID: https://orcid.org/0000-0002-1668-8773)
- Yu Xiu
- Xingming Shi (ORCID: https://orcid.org/0000-0003-4920-0989)
- Nan Li (ORCID: https://orcid.org/0000-0003-0942-7740)
- K S Lu
- Songqiang Huang (ORCID: https://orcid.org/0000-0003-0085-5765)
Institutions
- Southern University of Science and Technology (CN)
- Zhengzhou Children's Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Zaozhuang University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1633882
- Citations
- 1
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province