Figure S12 from SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer
<p>Combination of AZD4573 and talazoparib was effective in targeting SMARCA4/2-deficient ovarian cancer cells and was well-tolerated in mice</p>
Authors
- Zheng Fu (ORCID: https://orcid.org/0009-0004-2906-5729)
- Virginie Pilon (ORCID: https://orcid.org/0009-0009-7253-8233)
- W. Glenn McCluggage (ORCID: https://orcid.org/0000-0001-9178-4370)
- Yibo Xue (ORCID: https://orcid.org/0000-0003-4252-4446)
- Anie Monast (ORCID: https://orcid.org/0000-0002-0774-0090)
- Alexander J.R. Bishop (ORCID: https://orcid.org/0000-0002-5742-4387)
- Giulio Aceto (ORCID: https://orcid.org/0009-0007-2733-0850)
- Walter H. Gotlieb (ORCID: https://orcid.org/0000-0001-6227-6369)
- William D. Foulkes (ORCID: https://orcid.org/0000-0001-7427-4651)
- Azadeh Arabzadeh (ORCID: https://orcid.org/0009-0001-4128-1393)
- Xianbing Zhu (ORCID: https://orcid.org/0009-0002-5279-1847)
- Douglas A. Levine (ORCID: https://orcid.org/0000-0003-1038-8232)
- Alica Valachová
- Brian Raught (ORCID: https://orcid.org/0000-0001-6145-4776)
- Kitty Pavlakis (ORCID: https://orcid.org/0000-0002-1155-8638)
- Sidong Huang (ORCID: https://orcid.org/0000-0002-2838-4726)
- Amber Yasmeen (ORCID: https://orcid.org/0000-0002-7445-3032)
- Jonathan St‐Germain (ORCID: https://orcid.org/0000-0003-1640-6964)
- Leora Witkowski (ORCID: https://orcid.org/0000-0002-5736-2534)
- Geneviève Morin (ORCID: https://orcid.org/0009-0009-6398-9593)
- Jingjie Guo (ORCID: https://orcid.org/0009-0006-4615-6192)
- Nicklas Bassani (ORCID: https://orcid.org/0000-0001-9407-7348)
- Jutta Steinberger (ORCID: https://orcid.org/0009-0002-1477-2960)
- David G. Huntsman (ORCID: https://orcid.org/0000-0003-4934-3322)
- Yemin Wang (ORCID: https://orcid.org/0000-0002-2970-9510)
- Morag Park (ORCID: https://orcid.org/0000-0001-5400-606X)
- Selim Mısırlıoğlu (ORCID: https://orcid.org/0000-0002-5390-6637)
- Yuxuan Qi
- Lili Fu (ORCID: https://orcid.org/0000-0002-9376-1591)
- Kexin Liu (ORCID: https://orcid.org/0009-0008-0471-3557)
- Elise Graulich (ORCID: https://orcid.org/0000-0001-6517-4667)
- Racim Sansal
Publication Details
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1158/0008-5472.29918713
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00