IL-10/STAT5 axis suppresses miR-140 to upregulate B7-H4 expression in RAW264.7 cells
In summary, IL-10 can inhibit miR-140 through STAT5, thereby upregulating the expression of B7-H4 in RAW264.7 cells. This study may suggest a new mechanism underlying IL-10-mediated B7-H4 upregulation in macrophages.
Authors
- Dandan Zhu (ORCID: https://orcid.org/0000-0002-2849-4781)
- Wenxi Gao (ORCID: https://orcid.org/0000-0001-9077-8964)
- Weiliang Fan (ORCID: https://orcid.org/0000-0003-4570-7686)
- Yinong Duan (ORCID: https://orcid.org/0000-0001-5824-5762)
- Guo Chen (ORCID: https://orcid.org/0000-0001-8886-1873)
- Cheng Ji (ORCID: https://orcid.org/0000-0002-9287-6979)
- Pei Shen
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3389/fcimb.2025.1613297
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Nantong University