Neuroprotective and anticonvulsant effect of trimetazidine in a PTZ-kindling model of mice through modulation of the IL-1β/IL-1R1 and HMGB-1/TLR-4 axis
TMZ, at doses of 10 and 20 mg/kg p.o., demonstrated anticonvulsant and antioxidant activity, suppressed kindling progression, and restored neurotransmitter balance. Furthermore, TMZ has shown anti-inflammatory activity against neuroinflammation during epilepsy.
Authors
- Divya Vohora (ORCID: https://orcid.org/0000-0003-1852-9191)
- Shahnawaz Ahmad (ORCID: https://orcid.org/0000-0003-4712-3561)
- Seema Jain (ORCID: https://orcid.org/0000-0001-7677-4190)
- Mohd Samim (ORCID: https://orcid.org/0000-0003-1667-8572)
- Nidhi Agarwal (ORCID: https://orcid.org/0000-0002-2509-3026)
Institutions
- University of Delhi (IN)
- University College of Medical Sciences (IN)
- Jamia Hamdard (IN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3389/fphar.2025.1621729
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Hamdard National Foundation