The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target
Our study identifies PLEK as a prognostic biomarker and functional regulator in OS. It promotes an immune-infiltrated, metabolically active tumor microenvironment and is associated with attenuated malignant phenotypes <i>in vitro</i>. These findings highlight PLEK as a promising target for immunometabolic modulation in OS.
Authors
- Xuechen Ren
- Xianhui Qin (ORCID: https://orcid.org/0000-0001-7812-7982)
- Jianning Kang
- Li Zheng (ORCID: https://orcid.org/0000-0002-7033-4802)
- Yunpeng Zou (ORCID: https://orcid.org/0000-0003-3311-5931)
- Wei Jiang (ORCID: https://orcid.org/0000-0002-1374-053X)
- Shengbo Zhu (ORCID: https://orcid.org/0009-0000-1296-5772)
- Ying Zhang (ORCID: https://orcid.org/0009-0007-0777-1704)
- Hongbo Li (ORCID: https://orcid.org/0000-0003-4002-0252)
- Kai Zhao (ORCID: https://orcid.org/0000-0002-3613-1913)
- Xiang Lü (ORCID: https://orcid.org/0000-0001-6332-7885)
- Jiangbo Zhong
- Jianzhao Niu
Institutions
- Weifang Medical University (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Shandong University (CN)
- Jinan Central Hospital (CN)
- Lanzhou University Second Hospital (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Shandong First Medical University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1651858
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- Shandong First Medical University