Pharmacological inhibition of IL12β is effective in treating pressure overload-induced cardiac inflammation and heart failure
These findings indicate that pharmacological inhibition of IL12β effectively protected the heart from systolic overload-induced inflammation, remodeling, and dysfunction by reducing the proinflammatory signaling from both innate and adaptive immune responses.
Authors
- Umesh Bhattarai (ORCID: https://orcid.org/0009-0003-4042-836X)
- Ziru Niu (ORCID: https://orcid.org/0000-0002-2629-3484)
- Joshua S. Speed (ORCID: https://orcid.org/0000-0002-0131-5253)
- John S. Clemmer (ORCID: https://orcid.org/0000-0003-2250-2960)
- Xiaochen He (ORCID: https://orcid.org/0000-0002-8266-5895)
- Lihong Pan (ORCID: https://orcid.org/0000-0002-1995-2373)
- Hao Wang (ORCID: https://orcid.org/0000-0002-0834-3986)
- Dongzhi Wang (ORCID: https://orcid.org/0000-0003-1232-8807)
- Yingjie Chen (ORCID: https://orcid.org/0000-0002-4059-7847)
- Jian‐Xiong Chen (ORCID: https://orcid.org/0000-0001-9203-4336)
- Heng Zeng (ORCID: https://orcid.org/0000-0001-8559-2807)
Institutions
- University of Mississippi Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1624940
- Citations
- 2
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 2.78