Metabolomics Network Analysis of Various Genotypes Associated with Schizophrenia Gene Variant
The findings suggest that NOS1AP-rs12742393 contributes to complex metabolic alterations involving amino acids, organic compounds, fatty acids, and cholic acids. Moreover, serum metabolome analysis demonstrates sufficient sensitivity and specificity to provide insights into NOS1AP-rs12742393 genotype-associated metabolic profiles, supporting a network-based approach to understanding schizophrenia susceptibility.
Authors
- Vassilios Fanos (ORCID: https://orcid.org/0000-0003-2617-2890)
- Michele Mussap (ORCID: https://orcid.org/0000-0002-3417-1284)
- Martina Spada (ORCID: https://orcid.org/0009-0003-9592-1178)
- Antonio Noto (ORCID: https://orcid.org/0000-0003-3538-0050)
- Mirko Manchia (ORCID: https://orcid.org/0000-0003-4175-6413)
- Hema Sekhar Reddy Rajula (ORCID: https://orcid.org/0000-0003-4667-8143)
- Cristina Piras (ORCID: https://orcid.org/0000-0003-0750-4837)
- Luigi Atzori (ORCID: https://orcid.org/0000-0002-0606-4959)
- Karolina Krystyna Kopeć (ORCID: https://orcid.org/0009-0006-0159-8253)
- Katia Lilliu
Institutions
- Dalhousie University (CA)
- University of Cagliari (IT)
Publication Details
- Journal
- Metabolites
- Published
- 2025-08-15
- DOI
- https://doi.org/10.3390/metabo15080551
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00