Cutaneous Manifestations of Liver Cirrhosis: Clinical Significance and Diagnostic Implications

Liver cirrhosis, a progressive and often irreversible condition, exerts widespread systemic effects, with the skin frequently serving as a visible window into the extent of hepatic dysfunction. Cutaneous manifestations, such as spider angiomas, palmar erythema, jaundice, and pruritus, not only reflect underlying pathophysiologic changes but also serve as important, non-invasive diagnostic and prognostic markers of disease severity. Early detection of such cutaneous findings may allow for early treatment, optimize patient management, and improve outcomes. This review addresses the various cutaneous manifestations of liver cirrhosis, their pathogenesis, and their prognostic and diagnostic importance, emphasizing the need for heightened clinical awareness of the improvement in patient care.

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Publication Details

Journal
Livers
Published
2025-08-15
DOI
https://doi.org/10.3390/livers5030037
Primary Topic
Hepatitis C virus research
Type
article
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article

Cutaneous Manifestations of Liver Cirrhosis: Clinical Significance and Diagnostic Implications

Amelia Liu, Jeffrey B. Travers, Rebecca Reese, Craig A. Rohan et al.
Livers
Hepatitis C virus research
article

Cutaneous Manifestations of Liver Cirrhosis: Clinical Significance and Diagnostic Implications

Amelia Liu, Jeffrey B. Travers, Rebecca Reese, Craig A. Rohan, Yazan Abboud, Risha Annamraju, Tian Chen, Colleen Doyle, Rita Kamoua, Adriana Parella
article en

Abstract

Liver cirrhosis, a progressive and often irreversible condition, exerts widespread systemic effects, with the skin frequently serving as a visible window into the extent of hepatic dysfunction. Cutaneous manifestations, such as spider angiomas, palmar erythema, jaundice, and pruritus, not only reflect underlying pathophysiologic changes but also serve as important, non-invasive diagnostic and prognostic markers of disease severity. Early detection of such cutaneous findings may allow for early treatment, optimize patient management, and improve outcomes. This review addresses the various cutaneous manifestations of liver cirrhosis, their pathogenesis, and their prognostic and diagnostic importance, emphasizing the need for heightened clinical awareness of the improvement in patient care.

LiversVol. 5(3)
Rutgers, The State University of New Jersey (US), Wright State University (US), Rutgers New Jersey Medical School (US)
Good health and well-being
Openalex Percentile: Top 70%
Hepatitis C virus research
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Cutaneous Manifestations of Liver Cirrhosis: Clinical Significance and Diagnostic Implications — Amelia Liu, Jeffrey B. Travers, et al. · Livers (2025) | TGRS Research Map | TGRS