<scp>T2</scp> Hyperintensities in Gracile Tracts of Cervical Spinal Cord in Giant Axonal Neuropathy ( <scp>GAN</scp> )
The localization of spinal T-2 signal abnormalities to the cervical gracile tracts in GAN patients mirrors the localization of active dying-back axonal degeneration in GAN rodent models and suggests that these T2-signal abnormalities may be used as a surrogate marker of active axonal degeneration in the long tracts of the spinal cord in GAN and possibly other dying-back neurodegenerative diseases involving the spinal cord.
Authors
- Diana Xerxes Bharucha-Goebel (ORCID: https://orcid.org/0000-0002-7437-0982)
- Terry Hartman (ORCID: https://orcid.org/0000-0002-2007-802X)
- Diane Armao (ORCID: https://orcid.org/0000-0002-5540-5422)
- Joshua J. Todd (ORCID: https://orcid.org/0000-0001-7608-5184)
- Thomas W. Bouldin (ORCID: https://orcid.org/0000-0001-8963-9836)
- J. Keith Smith (ORCID: https://orcid.org/0000-0001-7588-3520)
- Rachel M. Bailey (ORCID: https://orcid.org/0000-0002-5909-5548)
- Dimah Saade (ORCID: https://orcid.org/0000-0003-1938-9952)
- Minal Jain (ORCID: https://orcid.org/0000-0002-1280-6971)
- Steven J. Gray
- Carsten G. Bönnemann
- M. Waite
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Iowa (US)
- National Institutes of Health (US)
- Children's National (US)
- National Institute of Neurological Disorders and Stroke (US)
- National Institutes of Health Clinical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Muscle & Nerve
- Published
- 2025-08-16
- DOI
- https://doi.org/10.1002/mus.70004
- Primary Topic
- Hereditary Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- University of Texas Southwestern Medical Center
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- NIH Clinical Center
- School of Medicine, University of North Carolina at Chapel Hill