Advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through RAGE/AKT/mTOR/glycolysis pathway
Our study indicated that AGE-induced inflammaging through binding to RAGE to activate the AKT/mTOR pathway and eventually enhancing glycolysis level, which may contribute to the increased inflammatory response triggered by LPS. These findings suggest that inflammaging is a critical mechanism through which AGEs exacerbate periodontitis.
Authors
- Yuehan Zhang (ORCID: https://orcid.org/0000-0003-2197-8617)
- Xuelian Chang (ORCID: https://orcid.org/0000-0003-4974-2585)
- Helin Chen
- Jiangzheng Shu (ORCID: https://orcid.org/0009-0007-4581-1607)
- Yufeng Qin (ORCID: https://orcid.org/0000-0002-3947-7610)
- Hongli Gao (ORCID: https://orcid.org/0000-0002-9288-4418)
- Lin Xiong (ORCID: https://orcid.org/0009-0008-6746-9918)
- Qiang Dong (ORCID: https://orcid.org/0000-0002-9622-1451)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Acta Odontologica Scandinavica
- Published
- 2025-08-21
- DOI
- https://doi.org/10.2340/aos.v84.44581
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Program of Guizhou Province