Effectiveness of a Covid mRNA Vaccine Against Two Early Variants: A Reanalysis of Published Data

Immortal time bias and healthy vaccinee bias have severely distorted estimates of Covid vaccine effectiveness. This analysis should be replicated in other observational studies to corroborate or refute the findings.

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Publication Details

Journal
Cureus
Published
2025-08-21
DOI
https://doi.org/10.7759/cureus.90666
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Effectiveness of a Covid mRNA Vaccine Against Two Early Variants: A Reanalysis of Published Data

Eyal Shahar
Cureus
SARS-CoV-2 and COVID-19 Research
article

Effectiveness of a Covid mRNA Vaccine Against Two Early Variants: A Reanalysis of Published Data

Eyal Shahar
article en

Abstract

Immortal time bias and healthy vaccinee bias have severely distorted estimates of Covid vaccine effectiveness. This analysis should be replicated in other observational studies to corroborate or refute the findings.

CureusVol. 17(8)
University of Arizona (US)
Zero hunger
Openalex Percentile: Top 74%
SARS-CoV-2 and COVID-19 Research
DOIOpen Access PDFOpenAlex
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Effectiveness of a Covid mRNA Vaccine Against Two Early Variants: A Reanalysis of Published Data — Eyal Shahar · Cureus (2025) | TGRS Research Map | TGRS