E2-based mRNA vaccine encapsulated in lipid nanoparticles protects pigs against classical swine fever virus
Classical swine fever virus (CSFV) remains a significant threat to the global pig industry. While live attenuated and subunit vaccines are currently in use, there is an urgent need for more effective and safer vaccination strategies. Here, we present a novel mRNA vaccine encoding the CSFV E2 glycoprotein, which provides protective immunity against the CSFV challenge in pigs. Our findings underscore the promising efficacy of this mRNA-based vaccine platform and offer an alternative strategy for CSFV prevention and control.
Authors
- Yingju Xia (ORCID: https://orcid.org/0000-0003-3106-1394)
- Jinzhong Lin (ORCID: https://orcid.org/0000-0002-2759-3243)
- Chuanwen Tian
- Weiqiang Guo (ORCID: https://orcid.org/0000-0001-8273-0338)
- Yebing Liu
- Jiaxin Li (ORCID: https://orcid.org/0000-0002-1237-542X)
- Ji Liu (ORCID: https://orcid.org/0000-0002-0345-5751)
- Zhiqiang Chen (ORCID: https://orcid.org/0000-0003-0242-6577)
- Jing Wen (ORCID: https://orcid.org/0000-0001-6225-1241)
- Hongjun Chen (ORCID: https://orcid.org/0000-0002-7254-7596)
- Zhenhua Xie
- Yingnan Liu (ORCID: https://orcid.org/0000-0001-7335-4422)
Institutions
- Fudan University (CN)
- Shanghai Veterinary Research Institute (CN)
- Zhongshan Hospital (CN)
- China Institute of Veterinary Drug Control (CN)
- Chinese Academy of Agricultural Sciences (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- Journal of Virology
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1128/jvi.00978-25
- Citations
- 2
- Primary Topic
- Animal Disease Management and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.81
Funders
- National Key Research and Development Program of China