How to control synaptic autophagy from the neuronal soma
Autophagy dysregulation at the neural synapse is a hallmark of Parkinson’s disease and has diverse molecular origins. New research in The EMBO Journal investigates the role of Drosophila Rab39, and uncovers a system for compartmentalized regulation of synaptic autophagy, with implications for our understanding of dysregulated synaptic proteostasis as observed in neurodegenerative diseases.
Authors
- Sheng Huang (ORCID: https://orcid.org/0000-0003-3328-3142)
- Stephan J. Sigrist (ORCID: https://orcid.org/0000-0002-1698-5815)
Institutions
- Technische Universität Berlin (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- The EMBO Journal
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1038/s44318-025-00535-9
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft