Behavioral subtypes impact prognosis and survival in amyotrophic lateral sclerosis: a clustering-based approach
Extending previous cross-sectional work, current findings offer delineation of the trajectory of clinical outcomes associated with classic behavioral phenotypes of ALS. Converging with past evidence of unique disease and progression profile in ALS patients with apathy, our work provides strong support for behavioral change and in particular apathy as a reliable indicator of poor prognosis across cross-sectional and longitudinal markers of clinical outcomes.
Authors
- Emma Devenney (ORCID: https://orcid.org/0000-0001-6140-0452)
- Chilan Nguyen (ORCID: https://orcid.org/0000-0002-9294-8071)
- Hannah C. Timmins (ORCID: https://orcid.org/0000-0001-5504-1625)
- Srestha Mazumder (ORCID: https://orcid.org/0000-0001-5322-5543)
- Nga Yan Tse (ORCID: https://orcid.org/0000-0002-1471-4835)
- Glenda Margaret Halliday (ORCID: https://orcid.org/0000-0003-0422-8398)
- Eleanor Ramsey
- William Huynh (ORCID: https://orcid.org/0000-0002-6504-8107)
- Matthew C. Kiernan (ORCID: https://orcid.org/0000-0001-9054-026X)
- Rebekah M. Ahmed (ORCID: https://orcid.org/0000-0001-6996-8317)
- Jashelle Caga (ORCID: https://orcid.org/0000-0003-4295-4366)
- Anneliese J Karjalainen
- Dayna-Lee Talbot
Institutions
- University of Notre Dame (US)
- The University of Melbourne (AU)
- Royal Prince Alfred Hospital (AU)
- UNSW Sydney (AU)
- Sydney Local Health District (AU)
- South Eastern Sydney Local Health District (AU)
- Neuroscience Research Australia (AU)
- The University of Notre Dame Australia (AU)
Publication Details
- Journal
- Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1080/21678421.2025.2522402
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Health and Medical Research Council