Outside Back Cover: Metal‐Responsive Up‐Regulation of Bifunctional Disulfides for Suppressing Protein Misfolding and Promoting Oxidative Folding (Angew. Chem. Int. Ed. 36/2025)
In their Research Article (e202502187), Keira Mori, Takahiro Muraoka, and co-workers developed a bifunctional compound containing metal-binding ligands and a redox-active disulfide, namely cyclam-SS, whose oxidative strength is up-regulated under metal stress for efficient protein folding. The cover image illustrates the bifunctional feature of cyclam-SS in the presence of stress-causing metal cations: suppression of metal-mediated protein misfolding and promotion of oxidative protein folding.
Authors
- Tomohide Saio (ORCID: https://orcid.org/0000-0003-3639-7399)
- Kenta Arai (ORCID: https://orcid.org/0000-0003-0785-2559)
- Masaki Okumura (ORCID: https://orcid.org/0000-0001-8130-2470)
- Yoshiaki Furukawa
- Motonori Matsusaki (ORCID: https://orcid.org/0000-0002-7296-033X)
- Takahiro Muraoka (ORCID: https://orcid.org/0000-0001-6744-048X)
- Tsubura Kuramochi
- Yojiro Hashiguchi (ORCID: https://orcid.org/0000-0002-6178-2574)
- Keita Mori (ORCID: https://orcid.org/0000-0003-3572-7384)
Institutions
- Tokai University (JP)
- Kanagawa Institute of Technology (JP)
- Tohoku University (JP)
- Keio University (JP)
- Massachusetts Institute of Technology (US)
- Tokushima University (JP)
- Tokyo University of Agriculture and Technology (JP)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1002/anie.202517793
- Primary Topic
- Enzyme Catalysis and Immobilization
- Type
- article
- Field-Weighted Citation Impact
- 0.00