Outside Front Cover: Conditional Stabilization of the Hypoxia‐Inducible Factor HIF1α: Photoswitchable Stapled Peptides Prevent Elongin BC–Mediated Degradation (Angew. Chem. Int. Ed. 36/2025)
The image illustrates the HIF1α-VHL signalling pathway as a set of interconnected gears. Our visible-light peptide, PSB-BCB-04, enables conditional stabilization of HIF-1α under normoxia by means of a tetra-ortho-fluoroazobenzene staple, whose cis conformation inhibits the VHL complex by disrupting the EloBC-pVHL interaction. Details of the study are reported by Olalla Vazquez et al. in their Communication (e202511183). Cover art image by M. Eugenio Vázquez (@glowsticks.bsky.social)
Authors
- Van Tuan Trinh (ORCID: https://orcid.org/0000-0003-1455-1826)
- Robert Liefke (ORCID: https://orcid.org/0000-0002-8549-637X)
- Heiko Geisler (ORCID: https://orcid.org/0000-0002-2536-5861)
- Frank Abendroth (ORCID: https://orcid.org/0000-0002-0320-2690)
- Olalla Vázquez (ORCID: https://orcid.org/0000-0002-7555-1865)
- Beatriz Pardo (ORCID: https://orcid.org/0000-0002-8219-5483)
- Lei Zhang (ORCID: https://orcid.org/0000-0003-4975-6821)
- Sabrina Fischer
Institutions
- Philipps University of Marburg (DE)
- Loewe Center for Synthetic Microbiology (DE)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1002/anie.202517898
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00